Imdusiran (AB-729)

Imdusiran is our RNAi therapeutic

Imdusiran is a subcutaneously-delivered RNA interference (RNAi) therapeutic specifically designed to reduce all HBV viral antigens, including hepatitis B surface antigen (HBsAg), which is thought to be a key prerequisite to enable reawakening of a patient’s immune system to respond to the virus. Imdusiran targets hepatocytes using our novel covalently conjugated N-acetylgalactosamine (GalNAc) delivery technology.

Clinical data to-date

Clinical data generated thus far has shown imdusiran to be generally safe and well-tolerated and to provide a robust and comparable decline in hepatitis B surface antigen and HBV DNA in patients regardless of dose, dosing interval or baseline characteristics. In addition, imdusiran continues to result in HBV-specific T-cell immune restoration and decrease of exhausted T-cells. Imdusiran is currently in two Phase 2a clinical trials in combination with other antiviral agents for the treatment of cHBV.