RNAi Collaborations & Partnerships

Since inception, Arbutus has fostered collaborations and partnerships with leading companies in the RNAi field, including Alnylam Pharmaceuticals, Inc., Dicerna Pharmaceuticals Inc., Merck & Co. Inc., Takeda Pharmaceutical Company, Monsanto, and other undisclosed pharmaceutical and biotechnology companies.

Our Partners


Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY)

Arbutus has granted a license to Alnylam to use Arbutus' LNP technology to enable RNAi therapeutic products. Arbutus will receive milestone and royalty payments as LNP-enabled products are developed and commercialized. Alnylam currently has three LNP-enabled products in human clinical trials: ALN-TTR02 (patisiran), ALN-VSP, and ALN-PCS02.


Alexion Pharmaceuticals, Inc. (Nasdaq: ALXN)

In March 2016, Arbutus granted a license to Alexion to use our proprietary lipid nanoparticle (LNP) technology in one of their rare disease messenger RNA (mRNA) programs, which will enable Alexion to address delivery for therapeutic application of mRNA and rapidly enter clinical development.

Spectrum Pharmaceuticals, Inc.

In 2006, Arbutus licensed three liposomal chemotherapy products to Talon Therapeutics: Marqibo® (a liposomal formulation of the chemotherapy drug vincristine); Alocrest (a liposomal formulation of the chemotherapy drug vinorelbine); and, Brakiva (a liposomal formulation of the chemotherapy drug topotecan). In 2013, Spectrum Pharmaceuticals, Inc. (Nasdaq: SPPI) acquired Talon Therapeutics. Spectrum has launched Marqibo® through its existing hematology sales force. Arbutus receives royalty payments based on Marqibo®’s commercial sales.

 Read more about our Partnered Products here.